This is a very technical article, but good information that could put older adults minds at rest regarding expectable sorts of memory issues, vs. those memory symptoms which could signal a more serious problem. – Molly Allen, PsyD
From Medscape Medical News > Neurology
Not All Memory Complaints Signal Trouble
September 29, 2011 — The type and number of older patients’ memory complaints can be useful in helping to decide whether follow-up cognitive assessment is warranted, new research suggests.
“Some complaints are more worrisome for cognitive decline, such as difficulty following a conversation due to memory and getting lost in familiar surroundings, whereas others, such as forgetting things from one second to the next (eg, walking into a room and forgetting why), reflect normal aging,” Rebecca England Amariglio, PhD, told Medscape Medical News.
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Dr. Rebecca England Amariglio
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In her research, Dr. Amariglio, a neuropsychologist from the Division of Cognitive and Behavioral Neurology, Brigham and Women’s Hospital, Boston, Massachusetts, and colleagues has also found that the more complaints a patient has, the more likely they are to have cognitive problems.
Their research was published online September 15 in the Journal of the American Geriatrics Society.
Specific Complaints Have Specific Meaning
Dr. Amariglio and colleagues used the cognitive function subcohort of the Nurses’ Health Study to determine whether the type and number of subjective memory complaints is related to performance on objective cognitive tests. They asked 16,964 women the following 7 questions about subjective memory complaints previously found to be useful in patients with possible cognitive impairment:
- Have you recently experienced any change in your ability to remember things? [Change in Memory]
- Do you have more trouble than usual remembering a short list of items, such as a shopping list? [Short List]
- Do you have trouble remembering things from one second to the next one? [One Second to the Next]
- Do you have much more trouble than usual remembering recent events? [Recent Events]
- Do you have any difficulty in understanding or following spoken instructions? [Understanding Instructions]
- Do you have more trouble than usual following a group conversation or plot in a TV program because of your memory? [Following a Conversation]
- Do you have trouble finding your way around familiar streets? [Getting Lost]
After gaining insight into the women’s subjective memory complaints, the researchers administered a battery of standard cognitive tests. The average age of the women was 74 years, and 98% of the participants were white.
Overall, 27% of women reported no subjective memory complaints, 53% reported 1 or 2, and 7% reported 4 or more. “Change in Memory” was the most common complaint, reported by 56% of the women, followed by the “Short List” complaint (29%) and the “One Second to the Next” complaint (25%). As expected in these generally healthy women, very few reported the “Getting Lost” complaint (<2%).
After adjusting for age and depressive symptoms and mutually adjusting each subjective memory complaint for all of the others, suggestions of specific associations were found between several complaints and impaired performance on individual cognitive measures.
For example, the “Getting Lost” complaint, which is indicative of dementia, was strongly associated with cognitive impairment, as expected, whereas the “One Second to the Next” complaint, which is associated with normal aging, was not related to cognitive impairment on any objective test.
Table. Memory Complaint and Risk for Impairment on Specific Cognitive Tests
| Complaint | TICS, Odds Ratio (95% CI) | Delayed Recall, Odds Ratio (95% CI) | Semantic Fluency, Odds Ratio (95% CI) | Confrontation Naming, Odds Ratio (95% CI) |
| Change in Memory | 1.16 (1.05 – 1.29) | 1.35 (1.22 – 1.49) | 1.05 (0.95 – 1.16) | 1.29 (1.07 – 1.55) |
| Short List | 1.23 (1.11 – 1.37) | 1.18 (1.07 – 1.30) | 0.98 (0.89 – 1.09) | 1.01 (0.84 – 1.21) |
| One Second to Next | 1.00 (0.89 – 1.11) | 0.96 (0.87 – 1.07) | 0.94 (0.84 – 1.05) | 1.01 (0.83 – 1.23) |
| Recent Events | 1.11 (0.99 – 1.26) | 1.24 (1.11 – 1.39) | 1.08 (0.96 – 1.22) | 1.08 (0.87 – 1.33) |
| Instructions | 1.31 (1.13 – 1.53) | 1.16 (1.00 – 1.34) | 1.28 (1.09 – 1.50) | 1.21 (0.93 – 1.58) |
| Conversations | 1.37 (1.15 – 1.64) | 1.42 (1.20 – 1.68) | 1.35 (1.13 – 1.62) | 1.62 (1.22 – 2.16) |
| Getting Lost | 2.22 (1.68 – 2.93) | 2.15 (1.65 – 2.82) | 1.71 (1.26 – 2.30) | 2.55 (1.69 – 3.85) |
TICS = Telephone Interview for Cognitive Status
CI = Confidence Interval
More Is Worse
In general, the more memory complaints a person had, the worse off their cognitive functioning was. Overall, when cognitive impairment was defined using the TICS or delayed recall, there was a roughly 20% greater likelihood of impairment with each additional subjective memory complaint.
For example, compared with participants with no memory complaints, the odds ratio for cognitive impairment on the TICS ranged from 1.19 (95% CI, 1.04 – 1.37) in women with 2 complaints to 4.34 (95% CI, 2.81 – 6.70) in women with 6 or 7 complaints.
For delayed recall, there was a significant increase in cognitive impairment beginning in participants with 1 subjective memory complaint, with odds ratios ranging from 1.33 (95% CI, 1.17 – 1.51) in those participants with 1 complaint to 4.95 (95% CI, 3.24 – 7.59) in those with 6 or 7 complaints.
These associations remained strong after adjusting for age and depressive symptoms.
Subjective Memory Complaints “Often Dismissed”
These findings, note Dr. Amariglio and colleagues, show that the quantity and type of subjective memory complaints appear to have “robust and sensible” relationships to cognitive measures.
They also suggest that physicians “should not discount subjective memory complaints of older patients because they may help to target individuals who require further cognitive examination,” the authors write.
In comments to Medscape Medical News, Dr. Amariglio encouraged clinicians to “listen for the types of memory complaints of their patients. Our results do not suggest complaints can replace cognitive testing, but rather they are a red flag that can alert clinicians to follow-up themselves or refer to a specialist.”
Reached for comment, Beth Snitz, PhD, assistant professor, Department of Neurology, University of Pittsburgh, Pennsylvania, who was not involved in the study, said, “It’s a significant study because the extremely large cohort (nearly 17,000 participants) shows a convincing picture of the systematic relationship between the number of subjective memory complaints and an increasing risk for cognitive impairment in older adults.
“Subjective complaints are often been dismissed by many healthcare professionals as signs of depression, stress, or simply a component of normal aging,” she noted. “But population-level evidence like the present study indicates that cognitive complaints in older adults confer a small but significant risk for current impairment and/or future decline. Querying about subjective concerns will likely have a role to play in primary care cognitive screening,” Dr. Snitz said.
The study was supported by the National Institutes of Health. The authors and Dr. Snitz have disclosed no relevant financial relationships.
J Am Geriatr Soc. 2011;59:1612-1617. Published online September 15, 2011. Abstract

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